Physician Advisory Board Reviewed
Research-Grade Peptide Education
Comprehensive educational resources on investigational peptides, reconstitution protocols, combination guidance, and dosing references — for research purposes only.
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Physician Advisory Board Reviewed
Research Protocols & Dosing Guides
Reconstitution Calculators
Fat Loss
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| Semaglutide | Reduces appetite, supports weight loss | 0.25–2.4 mg | Weekly | SubQ |
| Tirzepatide | Strong appetite control, fat loss | 2.5–15 mg | Weekly | SubQ |
| Retatrutide | Fat loss, appetite control | 2–12 mg | Weekly | SubQ |
| Cagrilintide | Reduces hunger, supports weight loss | 0.3–4.5 mg | Weekly | SubQ |
| AOD-9604 | Helps burn fat, protects muscle | 250–500 mcg | Daily | SubQ |
| Tesamorelin | Reduces belly fat, supports muscle growth | 1–2 mg | Daily | SubQ |
| CJC no DAC + Ipa | Improves recovery, muscle growth | 100–300 mcg each | Daily | SubQ |
| MOTS-C | Metabolism, energy, longevity | 5–10 mg | 2–3× weekly | SubQ |
| Survodutide | Reduces appetite, fat loss | 6 mg | Weekly | SubQ |
Muscle Building & Recovery
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| CJC no DAC + Ipa | Improves recovery, muscle growth | 100–300 mcg each | Daily | SubQ |
| IGF-LR3 | Muscle growth, recovery | 20–50 mcg | Daily / post-workout | IM / SubQ |
| TB-500 | Speeds healing, recovery | 2–5 mg | Weekly | SubQ / IM |
| BPC-157 | Heals injuries, gut support | 250–500 mcg | Daily | SubQ / IM |
| HCG | Supports testosterone, fertility | 250–500 IU | 2–3× weekly | SubQ |
| Sermorelin | Boosts growth hormone | 200–500 mcg | Daily | SubQ |
| Wolverine Stack | Muscle growth, recovery, healing | 1–5 mg | Per protocol | SubQ / IM |
| Pentadeca | Muscle growth | 10 mg | Daily | SubQ |
Cognitive, Mood & Sleep
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| Semax | Focus, memory, brain support | 300–600 mcg | Daily | SubQ |
| Selank | Reduces anxiety, calm mood | 300–600 mcg | Daily | SubQ |
| DSIP | Improves sleep quality | 100–300 mcg | Daily before bed | SubQ |
Overall Health & Wellbeing
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| Glutathione | Antioxidant, detox support | 200–600 mg | 1–3× weekly | IM |
| NAD+ | Energy, anti-aging support | 200 mg | 2–4× weekly | SubQ / IM |
| GHK-Cu | Skin, hair, healing | 1–2 mg | Daily | SubQ |
| Thymosin Alpha-1 | Immune support | 1–1.5 mg | 2–3× weekly | SubQ |
| KPV | Gut and inflammation support | 200–500 mcg | Daily | SubQ |
| LL-37 | Immune and infection support | 100–300 mcg | Daily (short cycles) | SubQ |
| Melanotan 1 | Skin tanning | 250–500 mcg | Daily | SubQ |
| Melanotan 2 | Tanning, libido | 250–500 mcg | Daily | SubQ |
| GLOW Stack | Skin, health, hormones, longevity | 1.5–2 mg | Daily | SubQ / IM |
| KLOW Stack | Fat loss, appetite, metabolism | 2.25 mg | Daily | SubQ |
Longevity & Cellular Health
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| Epitalon | Longevity, cellular repair | 5–10 mg | Daily (10–20 day cycle) | SubQ |
| MOTS-C | Metabolism, energy, longevity | 5–10 mg | 2–3× weekly | SubQ |
| SS-31 | Mitochondrial health | 5–10 mg | Daily | SubQ |
| NAD+ | Energy, anti-aging support | 200 mg | 2–4× weekly | SubQ / IM |
Sexual Health & Libido
| Peptide | What It Does | Dosing | Frequency | Route |
|---|---|---|---|---|
| Kisspeptin-10 | Hormone balance, libido | 100–300 mcg | 2–3× weekly | SubQ |
| PT-141 | Sexual desire | 1–2 mg | As needed | SubQ |
| Melanotan 2 | Tanning, libido | 250–500 mcg | Daily | SubQ |
| HCG | Hormone balance | 250–500 IU | 2–3× weekly | SubQ |
| Oxytocin | Mood, bonding, relaxation | 10–40 IU | As needed | SubQ |
Contraindications & Cautions
Pregnancy or breastfeeding
Active malignancy without oncology supervision
Personal/family history of medullary thyroid carcinoma or MEN2 (GLP-1 class)
Severe renal impairment or dehydration risk
Severe hepatic impairment without monitoring
History of pancreatitis or gallbladder disease (GLP-1 agents)
Uncontrolled cardiovascular disease or unstable arrhythmias
Autoimmune instability or immunosuppression
Concurrent investigational drug use or complex polypharmacy without oversight
Known hypersensitivity to any component, preservative, or diluent
Medical & Legal Disclaimer
This publication is provided for informational and educational purposes only and is not intended to constitute medical advice, diagnosis, or treatment. Certain products referenced may be investigational, compounded, or subject to regulatory restrictions that vary by jurisdiction. It is the sole responsibility of the prescribing provider to ensure compliance with all applicable laws and regulations.
Plan Your Peptides makes no representations or warranties regarding the safety, efficacy, or suitability of any information or protocol referenced, and disclaims any liability for damages arising from the use or misuse of this material. Clinical implementation and regulatory compliance are the reader's sole responsibility.
// Master Reference
Peptide Combination Guide
Safe pairings, combinations to avoid, and clinician-oversight cautions. For educational purposes only — not a personalized treatment plan.
Red-Light Rules — Read First
- Do not stack Semaglutide, Tirzepatide, Retatrutide, and Survodutide together. Use one incretin-family weight-loss agent at a time unless a specialist is explicitly directing otherwise.
- Do not casually stack multiple GH secretagogues/GHRH agents (CJC with DAC, CJC no DAC, Sermorelin, Tesamorelin, Ipamorelin, GHRP-2, GHRP-6, Hexarelin). That is duplicate pathway stimulation, not a "better stack."
- Avoid combining PT-141 with uncontrolled hypertension/cardiovascular disease or when reliable absorption of oral meds is needed the same day.
- Any combination involving HCG, Kisspeptin, or multiple reproductive-hormone agents should be clinician-supervised.
This is a high-level safety chart, not a personalized treatment plan. "Goes together" means commonly grouped by pathway or product category — not proven safe for self-use.
Master Pairing Chart
| Peptide | ✓ Often Grouped With | ✗ Avoid / Keep Separate |
|---|---|---|
| Blue Copper Serum (GHK-Cu topical) | Topical skincare routinesBPC-157 / TB-500 / KPV in regen-focused protocols | No major systemic interaction issue from topical useKeep separate from injectable assumptions — topical and injectable GHK-Cu are different product types |
| Wolverine Stack | BPC-157 + TB-500 by designKPV or GHK-Cu in repair/regeneration protocols | Do not add multiple extra GH secretagogues just because recovery is the goalIf using LL-37 or immune-active agents, clinician oversight is safer in infection/inflammation contexts |
| BPC-157 | TB-500KPVGHK-CuLL-37 or Thymosin Alpha-1 in immune/repair contexts | No strong human interaction datasetAvoid building giant "everything repair" stacks without a clear reason |
| Cagrilintide | Most evidence-based pairing is with semaglutide, not every metabolic peptide at once | Do not stack with semaglutide + tirzepatide + retatrutide/survodutide all togetherUse caution with other incretin/appetite agents — GI effects can compound |
| CJC-1295 with DAC | Usually kept in the GH-axis bucket with one companion secretagogue at most | Avoid stacking with CJC no DAC + Sermorelin + Tesamorelin + multiple GHRPs togetherNot a good idea to combine all GH releasers in one protocol |
| CJC-1295 no DAC | Often paired with IpamorelinSometimes paired with one GH-pathway companion | Avoid stacking with CJC with DAC, Sermorelin, Tesamorelin, GHRP-2, GHRP-6, Hexarelin all at once |
| CJC no DAC + Ipamorelin | Already a complete GH-secretagogue pair | Do not add multiple other GHRPs/GHRH analogs on top unless a specialist is directing it |
| Dihexa | SemaxSelankNAD+ in neuro/cognition protocols | Limited human safety data — avoid combining with multiple stimulating nootropics all at once |
| DSIP | Semax or Selank cautiously in neuro/sleep buckets | Avoid mixing into broad CNS stacks if you cannot separate what is helping or harming |
| Epitalon | NAD+MOTS-CSS-31Glutathione in longevity/mitochondrial buckets | No strong reason to combine with every longevity compound simultaneously |
| GHK-Cu (injectable) | BPC-157TB-500KPV in regeneration-focused groupings | Do not assume topical and injectable GHK-Cu are interchangeable |
| GHRP-2 | One GH-axis partner at most | Avoid stacking with GHRP-6 + Hexarelin + Ipamorelin + CJC/Sermorelin/Tesamorelin all together |
| GHRP-6 | One GH-axis partner at most | Avoid stacking with GHRP-2 + Hexarelin + Ipamorelin + multiple GHRH analogs together |
| GLOW Stack | GHK-Cu + BPC-157 + TB-500 by design | Do not keep adding every repair peptide without a clear objective |
| Hexarelin | One GH-axis partner at most | Avoid combining with several other GH secretagogues/GHRHs |
| HCG | Kisspeptin only with endocrine supervisionSometimes part of fertility or TRT-related care under a clinician | Do not self-stack casually with multiple reproductive-hormone agentsNeeds clinician oversight — endocrine interactions matter |
| IGF-1 LR3 | Usually kept separate from big GH-secretagogue stacks or used very selectively | Avoid piling on top of multiple GH releasers and growth-factor agents without specialist oversight |
| Ipamorelin | CJC no DAC is the classic pairingSometimes a single GHRH/GHRP companion | Avoid stacking with GHRP-2 + GHRP-6 + Hexarelin + Sermorelin + Tesamorelin + CJC with DAC all together |
| Kisspeptin | HCG only with reproductive/endocrine supervisionSometimes part of fertility-focused care | Do not casually combine with HCG/PT-141/other sex-hormone agents without clinician guidance |
| KLOW Stack | BPC-157 + TB-500 + KPV + GHK-Cu by design | Already broad — avoid reflexively layering LL-37, TA-1, and GH-axis agents on top without a clear plan |
| KPV | BPC-157TB-500GHK-CuLL-37 / Thymosin Alpha-1 in immune-repair contexts | No strong human interaction data — be careful with large immune-active stacks |
| LL-37 | BPC-157KPVThymosin Alpha-1 in immune/repair contexts | Needs extra caution — it is immune-active; avoid casual stacking with multiple immune-modulating agents |
| Melanotan I | Usually kept separate from PT-141 or Melanotan II unless specifically supervised | Avoid stacking multiple melanocortin agonists casually |
| Melanotan II | Usually kept separate from PT-141 or Melanotan I unless specifically supervised | Avoid stacking multiple melanocortin agonists casually |
| MOTS-C | NAD+SS-31EpitalonGlutathione in mitochondrial/longevity buckets | Do not add every metabolic peptide at once just because all are "mitochondrial" |
| NAD+ | MOTS-CSS-31GlutathioneEpitalon | Usually no specific pairing ban — but avoid using it to justify a huge multi-agent stack |
| PT-141 (Bremelanotide) | Usually kept in a separate sexual-health bucket, not as a general stack ingredient | Do not use with uncontrolled hypertension or known cardiovascular diseaseAvoid on days when oral medicines need reliable absorptionAvoid casually stacking with Melanotan I/II — overlapping melanocortin effects |
| Retatrutide | Usually used alone within the incretin/obesity class | Do not stack with semaglutide, tirzepatide, or other GLP-1-based weight-loss agents |
| Semax | SelankDihexa cautiouslyNAD+ in cognitive buckets | Avoid building overly complex nootropic stacks too fast |
| Selank | SemaxDihexa cautiouslyNAD+ in cognitive buckets | Avoid building overly complex nootropic stacks too fast |
| Sermorelin | Usually one GH-axis partner at most | Avoid stacking with CJCs + Tesamorelin + multiple GHRPs simultaneously |
| Semaglutide | If paired, only under a clinician — cagrilintide has published combination research | Do not combine with other GLP-1 receptor agonistsDo not stack with tirzepatide/retatrutide/survodutide casually |
| SS-31 | MOTS-CNAD+GlutathioneEpitalon | No strong formal pairing ban — but keep stacks simple and interpretable |
| TB-500 | BPC-157KPVGHK-CuLL-37 / Thymosin Alpha-1 selectively | Avoid giant "recovery" stacks without a clear reason and monitoring |
| Tesamorelin | Usually used alone in the GH-axis/metabolic bucket | Avoid combining with multiple GH secretagogues/GHRH analogsAvoid in active malignancy or pregnancy — use specialist oversight |
| Thymosin Alpha-1 | LL-37KPVBPC-157 / TB-500 in immune-repair buckets | Avoid casual use in very large immune-active stacks |
| Tirzepatide | Usually used alone within the incretin class | Do not combine with any GLP-1 receptor agonist or other tirzepatide productAvoid stacking with semaglutide/retatrutide/survodutide casually |
| Survodutide | Usually used alone within the next-gen metabolic class | Do not stack with semaglutide, tirzepatide, retatrutide, or other incretin-style weight-loss peptides |
| Glutathione | NAD+MOTS-CSS-31Epitalon | Support/adjunct compound — no reason to use it to justify a large unsupervised stack |
| Pentadeca Arginate | Usually grouped with performance/GH-axis catalogs, not all used together | Avoid piling onto IGF-1 LR3 + multiple GH secretagogues without specialist oversight |
Generally Go Together (by category)
- Repair / Regeneration: BPC-157, TB-500, KPV, GHK-Cu, sometimes LL-37 or Thymosin Alpha-1
- Mitochondrial / Longevity: NAD+, MOTS-C, SS-31, Epitalon, Glutathione
- Cognitive / Neuropeptide: Semax + Selank is the cleanest pair; Dihexa belongs in the same bucket but deserves extra caution
- Endocrine / Fertility: HCG and Kisspeptin belong in the same clinical bucket — specialist-managed only
Usually Do Not Belong Together
- Incretin / Obesity agents: Semaglutide, Tirzepatide, Retatrutide, and Survodutide — treat as one-lane drugs, not stacked
- GH-axis stimulators: CJC with DAC, CJC no DAC, Sermorelin, Tesamorelin, Ipamorelin, GHRP-2, GHRP-6, Hexarelin — do not pile together
- Melanocortin agonists: Melanotan I, Melanotan II, and PT-141 — do not casually stack
Needs the Most Caution
- Anything involving HCG, Kisspeptin, or multiple reproductive-hormone agents
- PT-141 in a person with blood-pressure or cardiovascular issues
- Tesamorelin in pregnancy, active malignancy, or disruption of the hypothalamic-pituitary axis
- Several investigational compounds at once — interaction data are often weak or absent
Source & Disclaimer
Red-light rules are based on: Wegovy prescribing information (semaglutide), Zepbound prescribing information (tirzepatide), Vyleesi prescribing information (bremelanotide), and Egrifta SV prescribing information (tesamorelin). For many research peptides there is no strong human combination evidence — caution rules are based on pathway overlap and absence of safety data, not proven incompatibility. This chart is not a personalized treatment plan.
// Research Tools
Peptide Reconstitution Calculator
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Dose Reference Table — All Common Doses
| Dose (mcg) | Syringe Units | Volume (mL) |
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